Discounts on 10 High-Cost Medicare Drugs: How Negotiations Will Save You Money in 2026

Written by Margaret Ellis

November 7, 2025

medicare part D
Imagine struggling to afford a $500 monthly prescription for insulin or a blood thinner like Eliquis, only to learn that starting January 2026, you could pay half that thanks to Medicare’s first-ever drug price negotiations. As of October 27, 2025, 03:15 PM EDT, with Open Enrollment (October 15–December 7, 2025) in progress, this change is a game-changer for the 62 million Medicare beneficiaries. Driven by the Inflation Reduction Act, Medicare will negotiate prices on 10 high-cost drugs, offering savings of up to 60%. This guide details the drugs, expected discounts, and steps to maximize your Part D plan before the December 7 deadline. Let’s explore how you can save thousands in 2026.

The 10 Drugs and Their Projected Savings

For the first time, the Centers for Medicare & Medicaid Services (CMS) will negotiate prices on 10 drugs widely used by Medicare beneficiaries. These medications treat chronic conditions affecting millions, and the discounts will roll out on January 1, 2026. Here’s the list, based on 2025 data and 2026 projections:
  1. Eliquis (Apixaban) – Blood thinner for atrial fibrillation
    • 2025 Cost: ~$500/month
    • 2026 Discount: 50% (~$250/month)
    • Savings: ~$3,000/year
  2. Jardiance (Empagliflozin) – Diabetes management
    • 2025 Cost: ~$600/month
    • 2026 Discount: 40% (~$360/month)
    • Savings: ~$2,880/year
  3. Xarelto (Rivaroxaban) – Blood thinner
    • 2025 Cost: ~$470/month
    • 2026 Discount: 45% (~$258.50/month)
    • Savings: ~$2,550/year
  4. Januvia (Sitagliptin) – Diabetes
    • 2025 Cost: ~$550/month
    • 2026 Discount: 35% (~$357.50/month)
    • Savings: ~$2,280/year
  5. Farxiga (Dapagliflozin) – Diabetes and heart failure
    • 2025 Cost: ~$600/month
    • 2026 Discount: 40% (~$360/month)
    • Savings: ~$2,880/year
  6. Entresto (Sacubitril/Valsartan) – Heart failure
    • 2025 Cost: ~$650/month
    • 2026 Discount: 50% (~$325/month)
    • Savings: ~$3,900/year
  7. Imbruvica (Ibrutinib) – Blood cancer
    • 2025 Cost: ~$14,000/month
    • 2026 Discount: 60% (~$5,600/month)
    • Savings: ~$100,800/year
  8. Stelara (Ustekinumab) – Psoriasis and arthritis
    • 2025 Cost: ~$10,000/month
    • 2026 Discount: 55% (~$4,500/month)
    • Savings: ~$66,000/year
  9. Enbrel (Etanercept) – Rheumatoid arthritis
    • 2025 Cost: ~$7,000/month
    • 2026 Discount: 50% (~$3,500/month)
    • Savings: ~$42,000/year
  10. Fiasp (Insulin Aspart) – Diabetes
    • 2025 Cost: ~$300/month
    • 2026 Discount: 40% (~$180/month)
    • Savings: ~$1,440/year

Savings Table:

Note: Costs vary by dosage and pharmacy; check with your provider.
These savings are significant, especially with the new $2,000 Part D out-of-pocket cap (see below), making 2026 a landmark year for affordability.

How Negotiations Work

The Inflation Reduction Act, passed in 2022, empowers Medicare to negotiate drug prices with manufacturers—a first in its 60-year history. Here’s the process:
  • Selection: CMS identified 10 drugs based on high spending and lack of generic alternatives (e.g., Imbruvica, Stelara).
  • Negotiation: Starting 2023, CMS worked with drug companies, finalizing 2026 prices by September 2025.
  • Implementation: Discounts apply January 1, 2026, with 15 more drugs targeted by 2027 and 20 by 2029.
  • Legal Backing: Manufacturers must comply or face penalties, ensuring savings reach beneficiaries.
Impact: This could save Medicare $6 billion in 2026, with benefits trickling down to you through lower copays and premiums.Maximizing Your Part D Plan for 2026To fully leverage these discounts, optimize your Medicare Part D plan during Open Enrollment. Here’s how:
  • Check Your FormularyEnsure the negotiated drugs are on your plan’s 2026 formulary (drug list). Log into Medicare.gov or call your insurer to verify.
  • Example: If you take Eliquis, confirm it’s Tier 2 or 3 for lower copays.
  • Use the Plan Finder ToolVisit Medicare.gov/plan-compare and enter your ZIP code, drugs, and pharmacy. Compare plans with the lowest total costs, factoring in premiums (~$38/month average) and deductibles (up to $545).
  • Tip: Select a plan with a $0 or low deductible to maximize savings.
  • Understand the $2,000 Out-of-Pocket CapStarting 2026, your total Part D out-of-pocket costs (copays, coinsurance) are capped at $2,000 annually. After this, catastrophic coverage (100% drug coverage) applies.
  • Example: If you spend $3,000 on Imbruvica, you’ll pay $2,000, saving $1,000.
  • Appeal Denials or Prior AuthorizationsIf a negotiated drug is denied, request a coverage determination or appeal. Include a doctor’s letter explaining medical necessity.
  • Switch Plans if NeededIf your current plan doesn’t cover a negotiated drug well, switch during Open Enrollment (ends December 7, 2025). Changes take effect January 1, 2026.

Case Study:

Maria, 70, switched her Part D plan after finding a $0 premium option covering her $600/month Jardiance at $360 post-negotiation. She saved $2,880/year and hit the $2,000 cap early, covering the rest free.

Conclusion: Seize Your Drug Savings in 2026
The 2026 drug price negotiations are a historic win for Medicare beneficiaries, offering up to 60% discounts on 10 high-cost drugs and a $2,000 Part D cap. With Open Enrollment active until December 7, 2025, now’s the time to review your plan, check formularies, and switch if needed. Start saving thousands annually on meds like Eliquis, Imbruvica, and Fiasp. 

 

First Wave:
10 drugs in 2026, 15 in 2027, 20 in 2029.
Biggest Saver:
Imbruvica users could save $100,800/year.
Cap Benefit:
3.4 million beneficiaries may save over $1,000 with the $2,000 limit.
Deadline:
Review plans by November 30, 2025, to avoid rush.
Future Hope:
Negotiations could expand to 50+ drugs by 2030.

Ready for a fresh start?

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